At Apexian, our mission is simple:
Find safe and effective therapies that will improve the lives of cancer patients.
Apexian is a biotechnology company focused on developing novel compounds to treat cancer. Our lead drug candidate – APX3330 – targets the APE1/Ref-1 redox protein, a molecule found in many cancers, including tumors of the colon, lung, breast, pancreas and others. Our experienced team of research scientists and clinical specialists will commence studies of APX3330 for the treatment of cancer in 2017.
Our scientific founder and Chief Scientific Officer, Dr. Mark R. Kelley, is the world’s leading expert in APE1/Ref-1 protein biology.
He is also the Betty and Earl Herr Chair in Pediatric Oncology Research and Professor in the Departments of Biochemistry & Molecular Biology and Pharmacology & Toxicology, Indiana University School of Medicine. Dr. Kelley is the Associate Director of the Herman B Wells Center for Pediatric Research and for Basic Science Research at the IU Simon Cancer Center.
Our science is unique and represents first-in-class therapeutic potential.
Inhibition of the APE1/Ref-1 redox protein affects signaling pathways critical to cancer cell survival, and APX3330 has shown dramatic anti-cancer effect in numerous pre-clinical models of human cancers. Our human studies will evaluate the safety and efficacy of APX3330 in patients with a variety of cancers that express the APE1/Ref-1 protein.
Our focus is on developing drugs to fight the most deadly cancers, most of which overexpress APE1
Our clinical development plan is focused on testing APX3330 against advanced cancers that express the APE1/Ref-1 protein. These advanced cancers constitute areas of high unmet medical need, and include deadly forms of cancer involving the lung, colon, breast, pancreas, brain and others. The APE1/Ref-1 protein is also expressed in certain pediatric and hematologic cancers, underscoring the importance of this molecular target.
LATEST APEXIAN NEWS
Apexian Chief Scientific Officer Awarded $2.3 Million National Cancer Institute Grant
Research focuses on Chemotherapy-Induced Peripheral Neuropathy
INDIANAPOLIS, Ind.—Apexian Pharmaceuticals’ Chief Scientific Officer, Dr. Mark Kelley, has been awarded $2.3 million by the National Cancer Institute (NCI) to research the effects of APX3330 on chemotherapy-induced peripheral neuropathy (CIPN). CIPN affects many cancer patients and can cause severe pain, loss of feeling, balance problems, muscle weakness, and even paralysis or organ failure. The symptoms may continue years after treatment ends. Currently, there is no effective treatment for CIPN.
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