Groundbreaking work
on cancers overexpressing APE1 protein.

Research and Development

apx3330Researchers at Apexian Pharmaceuticals have discovered several small molecules that inhibit redox signaling of APE1/Ref-1, a protein affecting a broad range of transcription factors known to be involved in cell survival, including NF-kB, AP-1, STAT3 and HIF.

  • Solid tumors: ¬†pancreatic, prostate, ovarian, glioblastoma
  • Liquid tumors: ¬†acute lymphoblastic leukemia (ALL), acute promyelocytic leukemia (APL)
  • Cancer-related side effects, such as Chemotherapy Induced Peripheral Neuropathy (CIPN)
  • Other anti-angiogenesis diseases such as age-related macular degeneration

+ See the pipeline status of Apexian Pharmaceutical’s work.