/* Apexian Pharmaceuticals, homepage, Design A: "Clinical editorial, light"
   Fonts: Fraunces (headlines, numerals), Inter (body, UI, data labels). No monospace (director, 26 Sep: max two fonts per box).
   Rule: every font-size is >= 16px, except .source-note (14px). */

:root {
  --white: #ffffff;
  --cloud: #f7f8fc;
  --tint: #f1f0fa;
  --line: #e4e4f0;
  --line-strong: #cbcbe0;
  --indigo: #282098;
  --indigo-deep: #1f1880;
  --ink: #15106b;
  --text: #1c1b33;
  --muted: #4c4b66;
  --emerald: #00a840;
  --violet: #8850d8;
  --magenta: #c858e8;

  --serif: "Fraunces", Georgia, "Times New Roman", serif;
  --sans: "Inter", system-ui, -apple-system, "Segoe UI", Roboto, Arial, sans-serif;

  --gutter: 48px;
  --max: 1240px;
  --section-y: 128px;
  --ease: cubic-bezier(.22, .61, .36, 1);

  --r-panel: 28px;
  --r-card: 20px;
  --r-btn: 14px;
  --r-pill: 999px;
}

*, *::before, *::after { box-sizing: border-box; }

html { -webkit-text-size-adjust: 100%; scroll-behavior: smooth; }

body {
  margin: 0;
  background: var(--white);
  color: var(--text);
  font-family: var(--sans);
  font-size: 18px;
  line-height: 1.6;
  font-weight: 400;
  -webkit-font-smoothing: antialiased;
  -moz-osx-font-smoothing: grayscale;
  overflow-x: hidden;
}

img { max-width: 100%; height: auto; display: block; }
svg { display: block; }
p { margin: 0; }
a { color: var(--indigo); }

h1, h2, h3 {
  margin: 0;
  font-family: var(--serif);
  font-weight: 300;
  color: var(--ink);
  font-optical-sizing: auto;
  letter-spacing: -0.015em;
}

strong { font-weight: 600; color: var(--ink); }

:focus-visible { outline: 2px solid var(--emerald); outline-offset: 3px; }

.container { width: 100%; max-width: calc(var(--max) + 2 * var(--gutter)); margin: 0 auto; padding: 0 var(--gutter); }

.visually-hidden {
  position: absolute !important; width: 1px; height: 1px; padding: 0; margin: -1px;
  overflow: hidden; clip: rect(0 0 0 0); white-space: nowrap; border: 0;
}

.skip-link {
  position: absolute; left: 16px; top: -60px; z-index: 100;
  background: var(--ink); color: var(--white); padding: 10px 16px; font-size: 16px;
}
.skip-link:focus { top: 12px; }

/* ---------- Header ---------- */
.site-header {
  position: sticky; top: 0; z-index: 50;
  background: rgba(255, 255, 255, .94);
  -webkit-backdrop-filter: saturate(1.4) blur(10px);
  backdrop-filter: saturate(1.4) blur(10px);
  border-bottom: 1px solid transparent;
  transition: border-color .4s var(--ease);
}
.site-header.is-scrolled { border-bottom-color: var(--line); }
.site-header__inner { display: flex; align-items: center; justify-content: space-between; height: 116px; }
.site-header__logo { display: block; }
.site-header__logo img { width: 160px; height: auto; }

.site-nav__list { display: flex; align-items: center; gap: 36px; list-style: none; margin: 0; padding: 0; }
.site-nav__list a {
  position: relative; display: inline-block; padding: 6px 0;
  font-size: 16px; font-weight: 500; color: var(--ink); text-decoration: none;
}
.site-nav__list a:not(.site-nav__contact)::after {
  content: ""; position: absolute; left: 0; right: 0; bottom: 0; height: 2px;
  background: var(--emerald); transform: scaleX(0); transform-origin: left;
  transition: transform .35s var(--ease);
}
.site-nav__list a:hover::after, .site-nav__list a[aria-current="page"]::after { transform: scaleX(1); }
.site-nav__contact {
  padding: 10px 22px !important; border: 1px solid var(--indigo); border-radius: var(--r-btn);
  transition: background-color .3s var(--ease), color .3s var(--ease);
}
.site-nav__contact:hover { background: var(--indigo); color: var(--white) !important; }

.nav-toggle {
  display: none; align-items: center; gap: 10px;
  background: none; border: 1px solid var(--line-strong); border-radius: var(--r-btn);
  padding: 10px 14px; font: 500 16px/1 var(--sans); color: var(--ink); cursor: pointer;
}
.nav-toggle__bars, .nav-toggle__bars::before, .nav-toggle__bars::after {
  display: block; width: 18px; height: 1.5px; background: var(--ink); position: relative;
  transition: transform .3s var(--ease), background-color .3s;
}
.nav-toggle__bars::before, .nav-toggle__bars::after { content: ""; position: absolute; left: 0; }
.nav-toggle__bars::before { top: -6px; }
.nav-toggle__bars::after { top: 6px; }
.nav-toggle[aria-expanded="true"] .nav-toggle__bars { background: transparent; }
.nav-toggle[aria-expanded="true"] .nav-toggle__bars::before { transform: translateY(6px) rotate(45deg); }
.nav-toggle[aria-expanded="true"] .nav-toggle__bars::after { transform: translateY(-6px) rotate(-45deg); }

/* ---------- Shared bits ---------- */
.block { padding: var(--section-y) 0; }

.chip {
  display: inline-flex; align-items: center; height: 36px; padding: 0 16px; border-radius: var(--r-pill);
  border: 1px solid rgba(40, 32, 152, .25); background: rgba(255, 255, 255, .7);
  font-family: var(--sans); font-size: 16px; font-weight: 500; letter-spacing: .02em; color: var(--indigo);
}
.eyebrow {
  display: flex; align-items: center; gap: 14px;
  font-family: var(--sans); font-size: 16px; color: var(--indigo); letter-spacing: .04em;
}
.eyebrow__mark { width: 32px; height: 2px; background: var(--emerald); }

.motif-underline {
  display: block; width: 120px; height: 3px; border-radius: 3px;
  background: linear-gradient(90deg, var(--violet), var(--magenta));
}
.motif-underline--wide { width: 160px; margin: 28px auto 0; }

.btn-row { display: flex; flex-wrap: wrap; gap: 14px; }
.btn-row--center { justify-content: center; }
.btn {
  display: inline-flex; align-items: center; justify-content: center;
  min-height: 54px; padding: 0 28px; border-radius: var(--r-btn);
  font-family: var(--sans); font-size: 16px; font-weight: 500; letter-spacing: .01em;
  text-decoration: none; transition: background-color .3s var(--ease), color .3s var(--ease), border-color .3s var(--ease);
}
.btn--primary { background: var(--indigo); color: var(--white); border: 1px solid var(--indigo); }
.btn--primary:hover { background: var(--ink); border-color: var(--ink); }
.btn--ghost { background: transparent; color: var(--indigo); border: 1px solid var(--line-strong); }
.btn--ghost:hover { border-color: var(--indigo); }

.text-link {
  display: inline-flex; align-items: center; gap: 10px; margin-top: 40px;
  font-size: 16px; font-weight: 500; color: var(--indigo); text-decoration: none;
  padding-bottom: 4px; border-bottom: 1px solid var(--line-strong);
  transition: border-color .3s var(--ease), gap .3s var(--ease);
}
.text-link:hover { border-bottom-color: var(--emerald); gap: 14px; }

.section-head { max-width: 900px; }
.section-head__index {
  display: flex; align-items: center; gap: 14px; margin-bottom: 28px;
  font-family: var(--sans); font-size: 16px; color: var(--indigo); letter-spacing: .04em;
}
.section-head__index::before { content: ""; flex: none; width: 32px; height: 2px; background: var(--emerald); }
.section-head__title { font-size: clamp(34px, 3.6vw, 52px); line-height: 1.12; }
.section-head__sub { margin-top: 20px; font-size: 20px; color: var(--muted); }
.section-head--center { margin: 0 auto; text-align: center; }
.section-head--center .section-head__index { justify-content: center; }
.section-head--split {
  display: grid; grid-template-columns: 3fr 9fr; gap: 40px; align-items: baseline; max-width: none;
}
.section-head--split .section-head__index { margin-bottom: 0; }

.source-note { margin-top: 56px; font-size: 14px; line-height: 1.55; color: var(--muted); max-width: 980px; }
.source-note--center { text-align: center; margin: 20px auto 0; }

.lead { font-size: 21px; line-height: 1.6; color: var(--text); }

/* ---------- Hero ---------- */
.hero { padding: 72px 0 104px; position: relative; overflow: hidden; }
.hero__grid {
  display: grid; grid-template-columns: minmax(0, 7fr) minmax(0, 5fr); gap: 40px; align-items: center;
  min-height: 600px;
}
.hero__text { position: relative; z-index: 1; padding: 24px 0 40px; }
.hero__title {
  margin: 28px 0 32px;
  font-size: clamp(46px, 6vw, 88px); line-height: 1.02; letter-spacing: -0.025em;
  max-width: 11.5em;
}
.hero__lede { margin: 32px 0 44px; max-width: 34em; font-size: 21px; line-height: 1.6; color: var(--muted); }

.hero__art { position: relative; align-self: stretch; display: flex; align-items: center; justify-content: center; }
.mark--hero { width: 128%; max-width: none; height: auto; overflow: visible; margin-right: -34%; filter: drop-shadow(0 18px 40px rgba(40, 32, 152, .14)); }
.mark__stripes path { fill: none; stroke-linecap: round; stroke-linejoin: round; }
.mark__stripes--cres path { stroke: var(--indigo); stroke-width: .95; }
.mark__stripes--green path { stroke: var(--emerald); stroke-width: 1.1; }
/* Hero: stripes draw in one after another along the arc (~1.8s), then undulate very slowly, phase-shifted per line. */
.mark--hero .mark__stripes path { stroke-dasharray: 1; stroke-dashoffset: 1; }
.mark--hero .mark__stripes--cres path {
  animation: draw 1s cubic-bezier(.45, .05, .25, 1) calc(.2s + var(--i) * .04s) forwards,
             fold 14s ease-in-out calc(2.2s + var(--i) * .45s) infinite alternate;
}
.mark--hero .mark__stripes--green path {
  animation: draw .9s cubic-bezier(.45, .05, .25, 1) calc(1.35s + var(--i) * .07s) forwards,
             fold 13s ease-in-out calc(2.6s + var(--i) * .6s) infinite alternate;
}
@keyframes fold {
  0% { transform: translate(0, 0); }
  25% { transform: translate(1.4px, -.9px); }
  50% { transform: translate(0, 0); }
  75% { transform: translate(-1.4px, .9px); }
  100% { transform: translate(0, 0); }
}
.mark--cta .mark__stripes path { stroke-width: 1.3; }
.mark__breathe { transform-box: view-box; transform-origin: 50% 50%; animation: breathe 14s ease-in-out 3s infinite alternate; }

@keyframes draw { to { stroke-dashoffset: 0; } }
@keyframes fade { to { opacity: 1; } }
@keyframes fillin { to { fill-opacity: 1; } }
@keyframes breathe {
  0% { transform: scale(1); opacity: 1; }
  100% { transform: scale(1.025); opacity: .93; }
}
@keyframes drift {
  0% { transform: translateY(-50%) rotate(-3deg); }
  100% { transform: translateY(-50%) rotate(3deg); }
}

.masthead {
  display: grid; grid-template-columns: repeat(4, minmax(0, 1fr));
  margin: 40px 0 0; padding: 28px 0 32px; border-top: 1px solid var(--line);
}
.masthead__item { padding-right: 24px; }
.masthead__item + .masthead__item { padding-left: 24px; border-left: 1px solid var(--line); }
.masthead dt { font-family: var(--sans); font-size: 16px; color: var(--muted); margin-bottom: 6px; }
.masthead dd { margin: 0; font-size: 18px; font-weight: 500; color: var(--ink); }

/* ---------- 01 Unmet need ---------- */
.need { background: var(--cloud); }
.need__grid {
  display: grid; grid-template-columns: minmax(0, 5fr) minmax(0, 6fr); gap: 8%;
  align-items: start; margin-top: 72px;
}

.umbrella { margin: 0; }
.umbrella__label { text-align: center; font-size: 18px; font-weight: 600; color: var(--ink); padding-bottom: 18px; }
.umbrella__bracket {
  position: relative; margin: 0 25%; height: 30px;
  border: 1.5px solid var(--indigo); border-bottom: 0; border-radius: 12px 12px 0 0;
}
.umbrella__bracket::before {
  content: ""; position: absolute; left: 50%; top: -17px; width: 1.5px; height: 16px;
  margin-left: -0.75px; background: var(--indigo);
}
.umbrella__cols { display: grid; grid-template-columns: 1fr 1fr; }
.umbrella__col { text-align: center; padding: 14px 8px 0; }
.umbrella__name { font-size: 18px; font-weight: 500; color: var(--ink); }
.umbrella__name span { display: block; color: var(--muted); font-weight: 400; }
.figure-num {
  margin-top: 18px; font-family: var(--serif); font-weight: 300; font-size: clamp(56px, 5.4vw, 80px);
  line-height: 1; color: var(--indigo); letter-spacing: -0.02em;
}
.figure-num__unit { font-size: 26px; letter-spacing: 0; }
.umbrella__geo { margin-top: 12px; font-family: var(--sans); font-size: 16px; color: var(--muted); }

.need__copy { display: grid; gap: 24px; padding-top: 4px; }
.need__copy p:not(.lead) { font-size: 18px; color: var(--muted); }

.stat-row {
  display: grid; grid-template-columns: 220px repeat(3, minmax(0, 1fr)); gap: 40px;
  margin-top: 96px; padding-top: 40px; border-top: 1px solid var(--line-strong);
}
.stat-row__label { font-family: var(--sans); font-size: 16px; color: var(--indigo); }

.stat__num, .outcome__num {
  font-family: var(--serif); font-weight: 300; line-height: 1; letter-spacing: -0.02em; color: var(--indigo);
  font-size: clamp(48px, 4.4vw, 64px); white-space: nowrap;
}
.stat__title, .outcome__title { margin-top: 18px; font-size: 18px; font-weight: 600; color: var(--ink); }
.stat__cap, .outcome__cap { margin-top: 4px; font-size: 16px; color: var(--muted); }

.stat-row--outcomes { border-top: 0; padding-top: 0; margin-top: 72px; }
.outcome { position: relative; padding-top: 28px; border-top: 1px solid var(--line-strong); }
.outcome::before {
  content: ""; position: absolute; left: 0; top: -2px; width: 56px; height: 3px; background: var(--emerald);
}
.stat-row--outcomes .stat-row__label { padding-top: 28px; }
.outcome__num { color: var(--ink); font-size: clamp(44px, 3.8vw, 56px); }

/* ---------- 02 Approach ---------- */
.approach { background: var(--white); }
.approach__grid { display: grid; grid-template-columns: minmax(0, 5fr) minmax(0, 7fr); gap: 80px; align-items: center; }
.approach__text .section-head__title { font-size: clamp(32px, 3vw, 44px); }
.approach__text p:not(.section-head__index) { margin-top: 24px; font-size: 18px; color: var(--muted); }
.approach__text .section-head__title + p { margin-top: 32px; font-size: 20px; color: var(--text); }

.moa { margin: 0; }
.moa__svg { width: 100%; height: auto; overflow: visible; }
.moa__svg--wide { max-width: 640px; margin-left: auto; }
.moa__svg--tall { display: none; max-width: 340px; margin: 0 auto; }
.moa__pill { fill: var(--white); stroke: var(--indigo); stroke-width: 1.25; }
.moa__pill--drug { fill: var(--indigo); stroke: var(--indigo); }
.moa__drug { font-family: var(--sans); font-size: 18px; font-weight: 600; fill: var(--white); letter-spacing: .02em; }
.moa__line { fill: none; stroke: var(--indigo); stroke-width: 1.25; stroke-linecap: round; stroke-linejoin: round; }
.moa__tbar { fill: none; stroke: var(--emerald); stroke-width: 3; stroke-linecap: round; }
.moa__arrow { fill: var(--indigo); }
.moa__ref { fill: var(--tint); stroke: var(--indigo); stroke-width: 1.25; }
.moa__refname { font-family: var(--serif); font-size: 28px; font-weight: 400; fill: var(--ink); }
.moa__tf { font-family: var(--sans); font-size: 19px; font-weight: 500; fill: var(--ink); }
.moa__note { font-family: var(--sans); font-size: 18px; fill: var(--muted); }
.moa__head { font-family: var(--sans); font-size: 18px; fill: var(--muted); }

/* ---------- 03 Profile (the one tinted section) ---------- */
.svg-defs { position: absolute; width: 0; height: 0; overflow: hidden; }
.profile { background: var(--tint); padding-top: 0; display: flow-root; }
.profile__panel {
  position: relative; z-index: 2; margin-top: -120px; padding: 96px 64px 72px;
  background: var(--white); border-radius: var(--r-panel); overflow: hidden;
  box-shadow: 0 50px 90px -40px rgba(21, 16, 107, .35), 0 12px 30px -12px rgba(21, 16, 107, .12), 0 0 0 1px rgba(21, 16, 107, .04);
}
.profile__panel::before {
  content: ""; position: absolute; left: 50%; top: 52%; width: 900px; height: 700px; transform: translate(-50%, -50%);
  background: radial-gradient(closest-side, rgba(40, 32, 152, .07), rgba(136, 80, 216, .05) 45%, rgba(136, 80, 216, 0) 100%);
  pointer-events: none;
}
.profile__panel > * { position: relative; }
.hex { margin: 64px auto 0; max-width: 1080px; }
.hex__svg { width: 100%; height: auto; overflow: visible; }
.hex__svg--tall { display: none; max-width: 340px; margin: 0 auto; }
.hex__fill { fill: url(#hexFill); }
.hex__outer { fill: none; stroke: var(--indigo); stroke-width: 1.5; stroke-linejoin: round; }
.hex__inner { fill: none; stroke: var(--indigo); stroke-opacity: .35; stroke-width: 1; stroke-linejoin: round; }
.hex__name { font-family: var(--serif); font-size: 44px; font-weight: 300; fill: var(--ink); letter-spacing: -0.01em; }
.hex__name--sm { font-size: 30px; }
.hex__sub { font-family: var(--sans); font-size: 20px; font-weight: 500; fill: var(--indigo); }
.hex__sub--sm { font-size: 17px; }
.hex__attr { pointer-events: bounding-box; cursor: default; }
.hex__leader { fill: none; stroke: var(--indigo); stroke-width: 1.25; stroke-linecap: round; stroke-linejoin: round; transition: stroke .35s var(--ease), stroke-width .35s var(--ease); }
.hex__dot { fill: var(--emerald); transform-box: fill-box; transform-origin: center; transition: transform .35s var(--ease); }
.hex__label { font-family: var(--sans); font-size: 20px; font-weight: 500; fill: var(--ink); transition: fill .35s var(--ease); }
.hex__num { font-family: var(--sans); font-size: 17px; font-weight: 500; fill: var(--indigo); }
.hex__attr:hover .hex__leader { stroke: var(--emerald); stroke-width: 2.25; }
.hex__attr:hover .hex__dot { transform: scale(1.5); }
.hex__attr:hover .hex__label { fill: var(--indigo); }

.hex__list { display: none; list-style: none; margin: 36px 0 0; padding: 0; }
.hex__list li {
  display: grid; grid-template-columns: 10px 1fr auto; column-gap: 16px; align-items: center;
  padding: 18px 4px; border-top: 1px solid var(--line);
}
.hex__list li:last-child { border-bottom: 1px solid var(--line); }
.hex__list-dot { width: 8px; height: 8px; border-radius: 50%; background: var(--emerald); box-shadow: 0 0 0 4px rgba(0, 168, 64, .12); }
.hex__list-text { font-size: 18px; font-weight: 500; color: var(--ink); line-height: 1.4; }
.hex__list-num { font-size: 16px; font-weight: 500; color: var(--muted); }

/* One-time reveal sequence: outline draws, fill and molecule arrive, then leaders draw outward one by one. */
.js .hex .hex__outer, .js .hex .hex__inner { stroke-dasharray: 1; stroke-dashoffset: 1; transition: stroke-dashoffset .8s var(--ease) .1s; }
.js .hex .hex__inner { transition-delay: .25s; }
.js .hex .hex__fill { opacity: 0; transition: opacity .5s ease .5s; }
.js .hex .hex__mol { opacity: 0; transform: scale(.9); transform-box: fill-box; transform-origin: center; transition: opacity .5s ease .7s, transform .5s var(--ease) .7s; }
.js .hex .hex__name, .js .hex .hex__sub { opacity: 0; transition: opacity .4s ease .9s; }
.js .hex .hex__leader { stroke-dasharray: 1; stroke-dashoffset: 1; transition: stroke-dashoffset .4s var(--ease) calc(1.1s + var(--k) * .12s), stroke .35s, stroke-width .35s; }
.js .hex .hex__dot, .js .hex .hex__label, .js .hex .hex__num { opacity: 0; transition: opacity .4s ease calc(1.3s + var(--k) * .12s), transform .35s var(--ease), fill .35s; }
.js .hex .hex__list li { opacity: 0; transform: translateY(8px); transition: opacity .4s ease calc(.9s + var(--k) * .12s), transform .4s var(--ease) calc(.9s + var(--k) * .12s); }
.js .hex.is-in .hex__outer, .js .hex.is-in .hex__inner, .js .hex.is-in .hex__leader { stroke-dashoffset: 0; }
.js .hex.is-in .hex__fill, .js .hex.is-in .hex__mol, .js .hex.is-in .hex__name, .js .hex.is-in .hex__sub,
.js .hex.is-in .hex__dot, .js .hex.is-in .hex__label, .js .hex.is-in .hex__num { opacity: 1; }
.js .hex.is-in .hex__mol { transform: none; }
.js .hex.is-in .hex__list li { opacity: 1; transform: none; }

.banner { margin: 72px auto 0; max-width: 900px; text-align: center; }
.banner__text {
  font-family: var(--serif); font-weight: 300; font-style: italic; color: var(--ink);
  font-size: clamp(24px, 2.4vw, 32px); line-height: 1.35;
}

/* ---------- 04 Human data ---------- */
.evidence { background: var(--white); }
.figures {
  display: grid; grid-template-columns: repeat(4, minmax(0, 1fr)); margin-top: 72px;
  border-top: 1px solid var(--line-strong);
}
.figure { padding: 40px 32px 8px 0; }
.figure + .figure { padding-left: 32px; border-left: 1px solid var(--line); }
.figure__num {
  display: inline-block; font-family: var(--serif); font-weight: 300; color: var(--indigo);
  font-size: clamp(56px, 6vw, 96px); line-height: 1; letter-spacing: -0.03em;
  padding-bottom: 16px; border-bottom: 2px solid var(--emerald);
}
.figure__title { margin-top: 22px; font-size: 18px; font-weight: 600; color: var(--ink); line-height: 1.4; }
.figure__cap { margin-top: 6px; font-size: 16px; color: var(--muted); }

/* ---------- 05 Pipeline ---------- */
.pipeline { background: var(--cloud); }
.pipe { margin-top: 72px; }
.pipe__table { width: 100%; border-collapse: collapse; table-layout: fixed; }
.pipe__col-program { width: 11%; }
.pipe__col-ind { width: 17%; }
.pipe__col-phase { width: 9%; }
.pipe__col-ms { width: 36%; }
.pipe__table thead th {
  padding: 0 0 16px; text-align: left; vertical-align: bottom;
  font-family: var(--sans); font-size: 16px; font-weight: 400; color: var(--muted);
  border-bottom: 1px solid var(--indigo);
}
.pipe__table thead th.pipe__phase-h { padding-left: 10px; border-left: 1px solid var(--line-strong); }
.pipe__table thead th:last-child { padding-left: 32px; }
.pipe__table tbody tr { border-bottom: 1px solid var(--line-strong); }
.pipe__table tbody th, .pipe__table tbody td { padding: 32px 0; vertical-align: middle; text-align: left; }
.pipe__program { font-family: var(--serif); font-size: 22px; font-weight: 400; color: var(--ink); }
.pipe__ind { font-size: 17px; color: var(--muted); padding-right: 16px !important; line-height: 1.45; }
.pipe__abbr { display: block; font-size: 18px; font-weight: 600; color: var(--ink); }
.pipe__track { padding: 0 !important; position: relative; height: 1px; }
.track { position: relative; height: 100%; min-height: 120px; }
.track::before {
  content: ""; position: absolute; inset: 0;
  background:
    linear-gradient(var(--line-strong), var(--line-strong)) 0 0 / 1px 100% no-repeat,
    linear-gradient(var(--line-strong), var(--line-strong)) 25% 0 / 1px 100% no-repeat,
    linear-gradient(var(--line-strong), var(--line-strong)) 50% 0 / 1px 100% no-repeat,
    linear-gradient(var(--line-strong), var(--line-strong)) 75% 0 / 1px 100% no-repeat;
}
.track__ticks { position: absolute !important; width: 1px; height: 1px; overflow: hidden; clip: rect(0 0 0 0); }
.track__bar {
  position: absolute; left: 0; top: 50%; width: 50%; height: 8px; margin-top: -4px;
  background: var(--indigo); border-radius: 0 4px 4px 0;
  transform-origin: left center;
}
.track__bar::after {
  content: ""; position: absolute; right: 0; top: 50%; width: 12px; height: 12px; margin: -6px -6px 0 0;
  border-radius: 50%; background: var(--white); border: 2px solid var(--emerald);
}
.track__trial {
  position: absolute; left: calc(50% + 14px); top: 50%; transform: translateY(-50%);
  font-family: var(--sans); font-size: 16px; font-weight: 600; color: var(--indigo); white-space: nowrap;
}
.pipe__ms { padding-left: 32px !important; font-size: 16px; color: var(--muted); line-height: 1.5; }
.pipe__ms p + p { margin-top: 4px; }
.pipe__trial-desc { color: var(--text); font-weight: 500; }
.pipe__funding { font-style: italic; }

/* ---------- 06 Leadership ---------- */
.team { background: var(--white); }
.team__head { display: grid; grid-template-columns: minmax(0, 8fr) minmax(0, 4fr); gap: 60px; align-items: end; }
.team__kol { margin-top: 24px; font-size: 20px; color: var(--muted); max-width: 36em; }
.team__years { border-left: 1px solid var(--line-strong); padding-left: 40px; }
.team__years-num { font-family: var(--serif); font-weight: 300; font-size: clamp(56px, 5.4vw, 84px); line-height: 1; color: var(--indigo); letter-spacing: -0.02em; }
.team__years-cap { margin-top: 12px; font-size: 18px; color: var(--ink); font-weight: 500; }

.people {
  list-style: none; margin: 80px 0 0; padding: 0;
  display: grid; grid-template-columns: repeat(6, minmax(0, 1fr)); gap: 40px 28px;
}
.person__photo {
  display: block; width: 112px; height: 112px; padding: 4px; border-radius: 50%;
  border: 1px solid var(--line-strong);
}
.person__photo img {
  width: 100%; height: 100%; object-fit: cover; border-radius: 50%;
  transform: scale(1.08); clip-path: circle(46.5%);
  background: var(--cloud);
}
.person__name { margin-top: 22px; font-size: 18px; font-weight: 600; color: var(--ink); line-height: 1.35; }
.person__cred { font-weight: 400; color: var(--muted); }
.person__role { margin-top: 6px; font-size: 16px; color: var(--muted); line-height: 1.45; }

/* ---------- 07 Publications ---------- */
.pubs { background: var(--cloud); }
.pubs__grid { display: grid; grid-template-columns: minmax(0, 4fr) minmax(0, 8fr); gap: 80px; }
.pubs .text-link { margin-top: 36px; }
.pub-list { list-style: none; margin: 0; padding: 0; border-bottom: 1px solid var(--line-strong); }
.pub { padding: 32px 0; border-top: 1px solid var(--line-strong); }
.pub__meta { display: flex; flex-wrap: wrap; gap: 6px 18px; font-family: var(--sans); font-size: 16px; }
.pub__journal { color: var(--indigo); }
.pub__year { color: var(--muted); }
.pub__title { margin-top: 12px; font-family: var(--serif); font-size: clamp(21px, 1.9vw, 26px); font-weight: 400; line-height: 1.3; }
.pub__title a { color: var(--ink); text-decoration: none; background: linear-gradient(var(--emerald), var(--emerald)) 0 100% / 0 1.5px no-repeat; transition: background-size .5s var(--ease); }
.pub__title a:hover { background-size: 100% 1.5px; }
.pub__authors { margin-top: 10px; font-size: 16px; color: var(--muted); }

/* ---------- Closing CTA ---------- */
.cta {
  position: relative; overflow: hidden; text-align: center; padding: 160px 0;
  background: radial-gradient(120% 90% at 85% 40%, #ecebfb 0%, rgba(236, 235, 251, 0) 60%), linear-gradient(180deg, #f7f8fc 0%, #f1f0fa 100%);
}
.cta__inner { position: relative; z-index: 1; }
.mark--cta {
  position: absolute; top: 50%; right: -260px; width: 980px; height: auto; opacity: .13;
  transform: translateY(-50%); transform-origin: 40% 50%; animation: drift 20s ease-in-out infinite alternate; pointer-events: none;
}
.cta__inner { max-width: 820px; }
.cta__title { font-size: clamp(38px, 4.4vw, 64px); line-height: 1.08; }
.cta__text { margin: 28px auto 44px; max-width: 34em; font-size: 20px; color: var(--muted); }

/* ---------- Footer ---------- */
.site-footer { background: var(--white); border-top: 1px solid var(--line); padding: 64px 0 48px; }
.site-footer__top { display: flex; justify-content: space-between; align-items: center; gap: 40px; flex-wrap: wrap; }
.site-footer__logo img { height: 64px; width: auto; }
.site-footer__nav { display: flex; flex-wrap: wrap; gap: 12px 32px; list-style: none; margin: 0; padding: 0; }
.site-footer__nav a { font-size: 16px; color: var(--ink); text-decoration: none; }
.site-footer__nav a:hover { color: var(--indigo); text-decoration: underline; text-decoration-color: var(--emerald); text-underline-offset: 6px; }
.site-footer__bottom {
  display: flex; justify-content: space-between; gap: 24px 40px; flex-wrap: wrap;
  margin-top: 48px; padding-top: 28px; border-top: 1px solid var(--line-strong);
  font-size: 16px; color: var(--muted);
}
.site-footer__disclaimer { max-width: 44em; }

/* ---------- v2: IBD footprint (slide 6, part 1) ---------- */
.footprint { background: var(--cloud); }
.footprint__title { font-size: clamp(30px, 2.9vw, 42px); line-height: 1.22; max-width: 26em; }
.footprint .section-head { max-width: 1040px; }
.fp { margin: 88px 0 0; --gap: 3px; --unit: calc((100% - 2 * var(--gap)) / 3); }
/* Band segments: CD 1/3, UC 1.3/3, rest 0.7/3 of the band length (minus two 3px gaps). */
.fp__total { text-align: center; }
.fp__total-num { font-family: var(--serif); font-weight: 300; font-size: clamp(48px, 5vw, 72px); line-height: 1; letter-spacing: -0.02em; color: var(--indigo); }
.fp__total-label { margin-top: 12px; padding-bottom: 8px; font-size: 18px; font-weight: 500; color: var(--ink); }
.fp__bracket {
  position: relative; height: 22px; margin: 50px 0 14px;
  border: 1px solid var(--indigo); border-bottom: 0; border-radius: 14px 14px 0 0;
}
.fp__bracket::before { content: ""; position: absolute; left: 50%; bottom: 100%; width: 1px; height: 30px; background: var(--indigo); }
.fp__band { position: relative; display: flex; gap: var(--gap); height: 72px; border-radius: var(--r-pill); overflow: hidden; }
.fp__band::after { content: ""; position: absolute; inset: 0; border-radius: var(--r-pill); box-shadow: inset 0 0 0 1px rgba(40, 32, 152, .45); pointer-events: none; }
.fp__seg { display: block; height: 100%; transform-origin: left center; }
.fp__seg--cd { flex: 0 0 calc((100% - 2 * var(--gap)) * 1 / 3); background: var(--indigo); }
.fp__seg--uc { flex: 0 0 calc((100% - 2 * var(--gap)) * 1.3 / 3); background: #6c63d6; }
.fp__seg--rest { flex: 1 1 0; background: #eeedfb; }
.fp__keys {
  display: grid; margin-top: 0;
  grid-template-columns: calc((100% - 2 * var(--gap)) * 1 / 3) calc((100% - 2 * var(--gap)) * 1.3 / 3) 1fr;
  column-gap: var(--gap);
}
.fp__key { position: relative; padding: 44px 16px 0 0; }
.fp__key::before { content: ""; position: absolute; left: 0; top: 0; width: 1px; height: 32px; background: var(--indigo); transform-origin: top; }
.fp__key--cd::before { left: 20px; }
.fp__key--cd { padding-left: 20px; }
.fp__key--rest::before { background: var(--line-strong); }
.fp__key-num { font-family: var(--serif); font-weight: 300; font-size: 40px; line-height: 1.05; letter-spacing: -0.01em; color: var(--ink); }
.fp__key-label { margin-top: 8px; font-size: 18px; color: var(--ink); }
.fp__key-label--muted { margin-top: 0; font-size: 16px; color: var(--muted); }
.fp__note { margin-top: 56px; font-size: 16px; color: var(--muted); }
.footprint .source-note { margin-top: 12px; }

/* ---------- v2: Treatment gap (slide 6, part 2) ---------- */
.gap { background: var(--white); }
.gap__grid { display: grid; grid-template-columns: minmax(0, 5fr) minmax(0, 7fr); gap: 6%; align-items: center; }
.gap__title { font-size: clamp(30px, 2.8vw, 42px); line-height: 1.2; }
.gap__text p:not(.section-head__index) { margin-top: 22px; font-size: 18px; color: var(--muted); }
.gap__text .gap__title + p { margin-top: 32px; }

.people-gap { display: flex; flex-direction: column; padding: 40px 36px 32px; background: var(--cloud); border-radius: var(--r-panel); }
/* Treatment gap (Al, 26 Sep 2026): two stats shown together; lit markers light up once when the card scrolls in. */
.gap-stat { padding: 32px 0; border-top: 1px solid var(--line-strong); }
.gap-stat:first-child { padding-top: 0; border-top: 0; }
.people-gap__num { font-family: var(--serif); font-weight: 300; font-size: clamp(56px, 5vw, 80px); line-height: 1; letter-spacing: -0.02em; color: var(--indigo); }
.people-gap__label { margin: 14px 0 22px; font-size: 18px; color: var(--ink); max-width: 30em; }

.markers { list-style: none; margin: 0; padding: 0; display: grid; grid-template-columns: repeat(10, minmax(0, 1fr)); gap: 12px; max-width: 600px; }
.marker {
  aspect-ratio: 1; border-radius: 50%; background: var(--white); border: 1.5px solid var(--line-strong);
  transition: background-color .7s var(--ease), border-color .7s var(--ease), box-shadow .7s var(--ease);
  transition-delay: calc(.5s + var(--n, 0) * 90ms);
}
.marker.is-on { background: var(--indigo); border-color: var(--indigo); }
.js .people-gap .marker.is-on { background: var(--white); border-color: var(--line-strong); }
.js .people-gap.is-in .marker.is-on { background: var(--indigo); border-color: var(--indigo); }
.people-gap__key { display: flex; flex-wrap: wrap; align-items: center; gap: 8px 10px; padding-top: 22px; border-top: 1px solid var(--line-strong); font-size: 16px; color: var(--muted); }
.key { width: 14px; height: 14px; border-radius: 50%; display: inline-block; }
.key--on { background: var(--indigo); }
.gap .source-note { margin-top: 48px; }

/* ---------- v2: Market band (slide 6, part 3) ---------- */
.market { background: var(--ink); color: var(--white); padding: 96px 0 216px; }
.market__grid { display: grid; grid-template-columns: minmax(0, 6fr) minmax(0, 6fr); gap: 32px 8%; align-items: end; }
.section-head__index--light { color: #cfcbf5; }
.market__title { font-size: clamp(34px, 3.4vw, 52px); line-height: 1.12; color: var(--white); }
.split { display: flex; gap: 4px; height: 20px; margin-bottom: 64px; }
.split__seg { position: relative; flex: var(--share) 1 0; border-radius: var(--r-pill); transform-origin: left center; }
.split__seg--uc { background: #9e98ea; }
.split__seg--cd { background: var(--white); }
.split__label { position: absolute; left: 0; top: calc(100% + 12px); font-size: 18px; font-weight: 500; color: var(--white); white-space: nowrap; }
.market__line { font-size: 18px; color: #e3e1fa; }
.source-note--light { grid-column: 1 / -1; margin-top: 24px; color: #bdb9ea; }

/* ---------- v2: Signposts ---------- */
.signposts { background: var(--white); }
.signs { list-style: none; margin: 56px 0 0; padding: 0; display: grid; grid-template-columns: 1fr 1fr; column-gap: 64px; }
.signs li { border-top: 1px solid var(--line-strong); }
.signs li:nth-last-child(-n+2) { border-bottom: 1px solid var(--line-strong); }
.sign { display: grid; grid-template-columns: 1fr auto; column-gap: 24px; align-items: center; padding: 30px 0; text-decoration: none; }
.sign__title { font-family: var(--serif); font-size: 28px; font-weight: 400; color: var(--ink); line-height: 1.2; }
.sign__line { grid-column: 1; margin-top: 8px; font-size: 18px; color: var(--muted); line-height: 1.45; }
.sign__arrow { grid-column: 2; grid-row: 1 / span 2; font-size: 22px; color: var(--indigo); transition: transform .35s var(--ease); }
.sign:hover .sign__arrow { transform: translateX(6px); }
.sign:hover .sign__title { text-decoration: underline; text-decoration-color: var(--emerald); text-decoration-thickness: 1.5px; text-underline-offset: 6px; }

/* ---------- v2 motion (one time, on first view) ---------- */
.js .fp__bracket { clip-path: inset(-40px 50% 0 50%); transition: clip-path .9s var(--ease) .2s; }
.js .fp__band::after { clip-path: inset(0 100% 0 0); transition: clip-path 1s var(--ease) .6s; }
.js .fp__seg--cd, .js .fp__seg--uc { transform: scaleX(0); }
.js .fp__seg--cd { transition: transform .6s cubic-bezier(.5, 0, .5, 1) 1.4s; }
.js .fp__seg--uc { transition: transform .6s cubic-bezier(.5, 0, .5, 1) 2s; }
.js .fp__seg--rest { opacity: 0; transition: opacity .6s ease 1.1s; }
.js .fp__key, .js .fp__total, .js .fp__keys::before { opacity: 0; transform: translateY(10px); transition: opacity .7s ease 2.5s, transform .7s var(--ease) 2.5s; }
.js .fp__total { transform: none; transition-delay: 0s; }
.js .is-in .fp__bracket { clip-path: inset(-40px 0 0 0); }
.js .is-in .fp__band::after { clip-path: inset(0 0 0 0); }
.js .is-in .fp__seg { transform: none; opacity: 1; }
.js .is-in .fp__key, .js .is-in .fp__total, .js .is-in .fp__keys::before { opacity: 1; transform: none; }
.js .split__seg { transform: scaleX(0); transition: transform 1.3s var(--ease) .3s; }
.js .split__seg--cd { transition-delay: .8s; }
.js .is-in .split__seg { transform: none; }

/* ---------- Scroll reveal and diagram draw (JS adds .js and .is-in) ---------- */
.js .reveal { opacity: 0; transform: translateY(16px); transition: opacity 1s var(--ease), transform 1s var(--ease); }
.js .reveal.is-in { opacity: 1; transform: none; }

.js .draw .moa__line, .js .draw .hex__leader { stroke-dasharray: 1; stroke-dashoffset: 1; transition: stroke-dashoffset 1.6s var(--ease) .3s; }
.js .draw .moa__arrow, .js .draw .moa__tbar, .js .draw .hex__dot, .js .draw .hex__num { opacity: 0; transition: opacity .8s ease 1.5s; }
.js .is-in .draw .moa__line, .js .is-in .draw .hex__leader { stroke-dashoffset: 0; }
.js .is-in .draw .moa__arrow, .js .is-in .draw .moa__tbar, .js .is-in .draw .hex__dot, .js .is-in .draw .hex__num { opacity: 1; }

.js .track__bar { transform: scaleX(0); transition: transform 1.4s var(--ease) .2s; }
.js .is-in .track__bar { transform: scaleX(1); }
.js .track__trial { opacity: 0; transition: opacity .8s ease 1.3s; }
.js .is-in .track__trial { opacity: 1; }

/* ---------- Responsive ---------- */
@media (max-width: 1240px) {
  .people { grid-template-columns: repeat(3, minmax(0, 1fr)); }
}

@media (max-width: 1179px) {
  .hex__svg--wide { display: none; }
  .hex__svg--tall { display: block; }
  .hex__list { display: block; max-width: 560px; margin-left: auto; margin-right: auto; }
}

@media (max-width: 1100px) {
  :root { --section-y: 104px; --gutter: 40px; }
  .approach__grid { grid-template-columns: 1fr; gap: 56px; }
  .moa__svg--wide { margin: 0 auto; }
  .need__grid { grid-template-columns: 1fr; gap: 56px; }
  .umbrella { max-width: 560px; }
  .stat-row { grid-template-columns: repeat(3, minmax(0, 1fr)); gap: 32px; }
  .stat-row__label { grid-column: 1 / -1; }
  .stat-row--outcomes .stat-row__label { padding-top: 0; }
  .pubs__grid { grid-template-columns: 1fr; gap: 48px; }
}

@media (max-width: 979px) {
  .site-header__inner { height: 96px; }
  .site-header__logo img { width: 130px; }
  .nav-toggle { display: inline-flex; }
  .site-nav {
    position: absolute; left: 0; right: 0; top: 100%;
    background: var(--white); border-bottom: 1px solid var(--line);
    display: none;
  }
  .site-nav.is-open { display: block; }
  .site-nav__list { flex-direction: column; align-items: stretch; gap: 0; padding: 8px var(--gutter) 24px; }
  .site-nav__list li { border-top: 1px solid var(--line); }
  .site-nav__list li:first-child { border-top: 0; }
  .site-nav__list a { display: block; padding: 16px 0; font-size: 18px; }
  .site-nav__list a::after { display: none; }
  .site-nav__contact { margin-top: 16px; text-align: center; }

  .hero { padding-top: 40px; }
  .hero__grid { grid-template-columns: 1fr; min-height: 0; gap: 0; }
  .hero__grid { position: relative; }
  .hero__art { position: absolute; top: -24px; right: calc(-1 * var(--gutter) + 8px); width: 38%; max-width: 300px; margin: 0; pointer-events: none; z-index: 0; }
  .mark--hero { width: 100%; margin-right: 0; filter: none; }
  .mark--hero .mark__stripes path { stroke-width: 1.7; }
  .hero__text { padding-top: 0; }
  .masthead { grid-template-columns: 1fr 1fr; row-gap: 24px; }
  .masthead__item:nth-child(3) { padding-left: 0; border-left: 0; }

  .section-head--split { grid-template-columns: 1fr; gap: 0; }
  .section-head--split .section-head__index { margin-bottom: 28px; }

  .figures { grid-template-columns: 1fr 1fr; }
  .figure:nth-child(3) { padding-left: 0; border-left: 0; }
  .figure:nth-child(n+3) { border-top: 1px solid var(--line); margin-top: 32px; }

  .team__head { grid-template-columns: 1fr; gap: 40px; }
  .team__years { border-left: 0; padding-left: 0; border-top: 1px solid var(--line-strong); padding-top: 32px; }

  /* Pipeline: rows become stacked records */
  .pipe__table, .pipe__table tbody, .pipe__table tr, .pipe__table th, .pipe__table td { display: block; width: 100%; }
  .pipe__table colgroup, .pipe__table thead { display: none; }
  .pipe__table tbody tr { padding: 32px 0; border-bottom: 0; border-top: 1px solid var(--line-strong); }
  .pipe__table tbody tr:last-child { border-bottom: 1px solid var(--line-strong); }
  .pipe__table tbody th, .pipe__table tbody td { padding: 0; }
  .pipe__program { font-size: 20px; }
  .pipe__ind { margin-top: 4px; }
  .pipe__abbr { display: inline; margin-right: 6px; }
  .pipe__track { height: auto; margin-top: 24px; }
  .track { min-height: 0; height: auto; padding: 0 0 48px; }
  .track::before { top: 0; bottom: 0; }
  .track__ticks {
    position: relative !important; width: auto; height: auto; overflow: visible; clip: auto;
    display: grid; grid-template-columns: repeat(4, 1fr);
  }
  .track__ticks i { font-style: normal; font-family: var(--sans); font-size: 16px; color: var(--muted); padding: 0 0 12px 8px; }
  .track__bar { top: auto; bottom: 18px; margin-top: 0; }
  .track__trial { display: none; }
  .pipe__ms { padding: 20px 0 0 !important; }
}

@media (max-width: 719px) {
  .moa__svg--wide { display: none; }
  .moa__svg--tall { display: block; }
  .profile__panel { padding: 64px 32px 48px; }
}

@media (max-width: 600px) {
  :root { --gutter: 16px; --section-y: 80px; }
  body { font-size: 17px; }
  .hero__art { top: -20px; right: 0; width: 128px; }
  .hero__title { font-size: 44px; margin: 22px 0 26px; }
  .hero__lede { font-size: 18px; margin: 26px 0 32px; }
  .btn-row { flex-direction: column; align-items: stretch; }
  .masthead { grid-template-columns: 1fr; row-gap: 0; padding-top: 8px; }
  .masthead__item, .masthead__item + .masthead__item { padding: 16px 0; border-left: 0; border-bottom: 1px solid var(--line); }
  .masthead__item:last-child { border-bottom: 0; }

  .section-head__title { font-size: 32px; }
  .section-head__sub { font-size: 18px; }
  .lead { font-size: 19px; }
  .need__grid { margin-top: 48px; }
  .umbrella__name { font-size: 16px; }
  .figure-num { font-size: 52px; }
  .figure-num__unit { font-size: 20px; }

  .stat-row { grid-template-columns: 1fr; gap: 36px; margin-top: 64px; }
  .stat-row--outcomes { margin-top: 56px; gap: 40px; }

  .figures { grid-template-columns: 1fr; }
  .figure, .figure + .figure { padding: 32px 0 8px; border-left: 0; margin-top: 0; }
  .figure + .figure { border-top: 1px solid var(--line); }
  .figure__num { font-size: 64px; }

  .people { grid-template-columns: 1fr 1fr; gap: 40px 20px; }
  .person__photo { width: 104px; height: 104px; }
  .person__name { font-size: 17px; }

  .cta { padding: 112px 0; }
  .profile__panel { margin-top: -96px; padding: 48px 18px 40px; }
  .mark--cta { width: 560px; right: -300px; opacity: .11; }
  .cta__text { font-size: 18px; }
  .site-footer__top { flex-direction: column; align-items: flex-start; }
  .site-footer__nav { flex-direction: column; gap: 12px; }
}

@media (max-width: 1240px) {
  .gap__grid { grid-template-columns: 1fr; gap: 56px; }
}
@media (max-width: 1100px) {
  .market__grid { grid-template-columns: 1fr; }
}
@media (max-width: 760px) {
  .fp__band { height: 56px; }
  .fp__keys { display: block; margin-top: 0; position: relative; height: auto; }
  .fp__keys::before { content: ""; display: block; height: 20px;
    background: linear-gradient(var(--indigo), var(--indigo)) 20px 0 / 1px 100% no-repeat,
                linear-gradient(var(--indigo), var(--indigo)) calc((100% - 6px) / 3 + 3px) 0 / 1px 100% no-repeat; }
  .fp__key, .fp__key--cd { padding: 18px 0 18px 26px; border-top: 1px solid var(--line); }
  .fp__key::before, .fp__key--cd::before { left: 0; top: 26px; width: 12px; height: 12px; border-radius: 50%; }
  .fp__key--cd::before { background: var(--indigo); }
  .fp__key--uc::before { background: #6c63d6; }
  .fp__key--rest::before { background: #eeedfb; box-shadow: inset 0 0 0 1px rgba(40, 32, 152, .45); }
  .fp__key-num { font-size: 36px; }
  .signs { grid-template-columns: 1fr; }
  .signs li:nth-last-child(2) { border-bottom: 0; }
}
@media (max-width: 600px) {
  .people-gap { padding: 28px 18px 24px; margin: 0 -2px; }
  .gap-stat { padding: 26px 0; }
  .people-gap__num { font-size: 56px; }
  .markers { gap: 6px; }
  .market { padding: 80px 0 176px; }
  .sign__title { font-size: 24px; }
  .sign__line { font-size: 17px; }
}

@media (prefers-reduced-motion: reduce) {
  html { scroll-behavior: auto; }
  *, *::before, *::after { animation: none !important; transition: none !important; }
  .mark--hero .mark__stripes path { stroke-dashoffset: 0; }
  .js .reveal { opacity: 1; transform: none; }
  .js .draw .moa__line, .js .draw .hex__leader { stroke-dashoffset: 0; }
  .js .draw .moa__arrow, .js .draw .moa__tbar, .js .draw .hex__dot, .js .draw .hex__num { opacity: 1; }
  .js .hex .hex__outer, .js .hex .hex__inner, .js .hex .hex__leader { stroke-dashoffset: 0; }
  .js .hex .hex__fill, .js .hex .hex__mol, .js .hex .hex__name, .js .hex .hex__sub, .js .hex .hex__dot, .js .hex .hex__label, .js .hex .hex__num, .js .hex .hex__list li { opacity: 1; transform: none; }
  .js .track__bar { transform: none; }
  .js .track__trial { opacity: 1; }
  .js .fp__bracket, .js .fp__band::after { clip-path: none; }
  .js .fp__seg, .js .fp__key, .js .fp__total, .js .fp__keys::before { transform: none; opacity: 1; }
  .js .split__seg { transform: none; }
  .js .people-gap .marker.is-on { background: var(--indigo); border-color: var(--indigo); }
}

/* Director fix (24 Sep): on phones the colour dots link labels to segments; drop the dangling ticks. */
@media (max-width: 760px) {
  .fp__keys::before { display: none; }
  .fp__keys { margin-top: 20px; }
}

/* =====================================================================
   INNER PAGES (site v1, 26 Sep 2026). Everything below reuses the homepage
   vocabulary: tokens, hairlines, .chip, hero grid, .moa line language,
   the dark band + overlapping white panel (market/profile), .reveal.
   ===================================================================== */

/* ---------- Shared: keep hyphenated molecule names on one line ---------- */
.nowrap { white-space: nowrap; }

/* ---------- Shared: active nav item ---------- */
.site-nav__contact[aria-current="page"] { background: var(--tint); }
@media (max-width: 979px) {
  .site-nav__list a[aria-current="page"] { color: var(--indigo); text-decoration: underline; text-decoration-color: var(--emerald); text-decoration-thickness: 2px; text-underline-offset: 8px; }
  .site-nav__list a.site-nav__contact[aria-current="page"] { text-decoration: none; }
}

/* ---------- Shared: inner-page hero (homepage hero, smaller) ---------- */
.hero--page { padding: 56px 0 80px; }
.hero--page .hero__grid { min-height: 0; grid-template-columns: minmax(0, 8fr) minmax(0, 4fr); gap: 56px; }
.hero--page .hero__text { padding: 16px 0 8px; }
.hero--page .hero__title { margin: 26px 0 30px; font-size: clamp(38px, 4.1vw, 56px); line-height: 1.1; letter-spacing: -0.02em; max-width: 17em; }
.hero--page .hero__lede { margin: 30px 0 0; font-size: 20px; }
.hero--page .hero__art { justify-content: flex-end; }
.hero--page .mark--hero { width: 100%; max-width: 330px; margin: 0; }

/* ---------- Shared: dark band + overlapping white panel (homepage market + profile surfaces) ---------- */
.band { background: var(--ink); color: var(--white); padding: 96px 0 200px; }
.band__title { color: var(--white); }
.band__sub { margin-top: 20px; font-size: 20px; color: #e3e1fa; max-width: 40em; }
.overlap { background: var(--tint); padding-top: 0; display: flow-root; }
.overlap__panel {
  position: relative; z-index: 2; margin-top: -120px; padding: 72px 64px 56px;
  background: var(--white); border-radius: var(--r-panel);
  box-shadow: 0 50px 90px -40px rgba(21, 16, 107, .35), 0 12px 30px -12px rgba(21, 16, 107, .12), 0 0 0 1px rgba(21, 16, 107, .04);
}
.overlap__panel > .source-note { margin-top: 40px; }
.source-note a { color: var(--indigo); text-decoration: underline; text-decoration-color: var(--line-strong); text-underline-offset: 3px; }
.source-note a:hover { text-decoration-color: var(--emerald); }

/* ---------- Science: Ref-1 redox cycle (slide 8, left) ---------- */
.redox { background: var(--cloud); }
.redox .approach__text p { font-size: 18px; color: var(--muted); }
.rx .rx__svg--wide { max-width: 700px; margin-left: auto; }
.rx .rx__svg--tall { display: none; max-width: 360px; margin: 0 auto; }
.rx__refname { font-size: 24px; }
.rx__active { stroke: var(--emerald); stroke-width: 1.75; }
.rx__dna { fill: none; stroke-width: 2; stroke-linecap: round; }
.rx__dna--a { stroke: var(--indigo); }
.rx__dna--b { stroke: #6c63d6; }
.rx__x { fill: none; stroke: var(--emerald); stroke-width: 3; stroke-linecap: round; }
.js .draw .rx__x, .js .draw .rx__dna { opacity: 0; transition: opacity .8s ease 1.5s; }
.js .is-in .draw .rx__x, .js .is-in .draw .rx__dna { opacity: 1; }

/* ---------- Science: TF to IBD target map (slide 8, right) ---------- */
.tfmap { margin: 0; }
.tfmap__svg { width: 100%; max-width: 1010px; height: auto; margin: 0 auto; overflow: visible; }
.tfmap__line { fill: none; stroke: var(--indigo); stroke-width: 1.5; stroke-linecap: round; }
.tfmap__arrow { fill: var(--indigo); }
.tfmap__tie { fill: none; stroke: var(--indigo); stroke-width: 1.5; }
.tfmap__box rect { fill: var(--cloud); stroke: var(--line-strong); stroke-width: 1.25; }
.tfmap__title { font-family: var(--sans); font-size: 20px; font-weight: 600; fill: var(--ink); }
.tfmap__sub { font-family: var(--sans); font-size: 20px; font-weight: 400; fill: var(--muted); }
.tfmap__tf { cursor: pointer; outline: none; }
.tfmap__tf rect { fill: var(--white); stroke: var(--indigo); stroke-width: 1.25; }
.tfmap__tf text { font-family: var(--sans); font-size: 21px; font-weight: 500; fill: var(--ink); }
.tfmap__tf:focus-visible rect { stroke: var(--emerald); stroke-width: 2.5; }
.tfmap [data-for] { transition: opacity .35s var(--ease); }
.tfmap.is-focus [data-for]:not(.is-hl) { opacity: .16; }
.tfmap.is-focus .tfmap__link.is-hl .tfmap__line { stroke: var(--emerald); stroke-width: 2.5; }
.tfmap.is-focus .tfmap__link.is-hl .tfmap__arrow { fill: var(--emerald); }
.tfmap.is-focus .tfmap__tf.is-hl rect { fill: var(--indigo); stroke: var(--indigo); }
.tfmap.is-focus .tfmap__tf.is-hl text { fill: var(--white); }
.tfmap.is-focus .tfmap__box.is-hl rect { fill: var(--white); stroke: var(--indigo); }
.tfmap__line, .tfmap__arrow, .tfmap__tf rect, .tfmap__tf text, .tfmap__box rect { transition: stroke .35s var(--ease), fill .35s var(--ease), stroke-width .35s var(--ease); }
/* One-time draw of the connections on first view */
.js .tfmap .tfmap__line { stroke-dasharray: 1; stroke-dashoffset: 1; transition: stroke-dashoffset 1.4s var(--ease) calc(.4s + var(--k) * .16s), stroke .35s var(--ease), stroke-width .35s var(--ease); }
.js .tfmap .tfmap__arrow { opacity: 0; transition: opacity .6s ease calc(1.5s + var(--k) * .16s), fill .35s var(--ease); }
.js .tfmap.is-in .tfmap__line { stroke-dashoffset: 0; }
.js .tfmap.is-in .tfmap__arrow { opacity: 1; }

/* Narrow screens: one block per TF with its targets underneath */
.tflist { display: none; }
.tflist__tf + .tflist__tf { margin-top: 36px; }
.tflist__name {
  display: inline-flex; align-items: center; height: 48px; padding: 0 26px; border: 1.25px solid var(--indigo); border-radius: var(--r-pill);
  font-size: 19px; font-weight: 500; color: var(--ink);
}
.tflist__targets { list-style: none; margin: 0 0 0 24px; padding: 0; }
.tflist__targets li { position: relative; padding: 18px 0 16px 30px; border-left: 1.5px solid var(--indigo); }
.tflist__targets li::before { content: ""; position: absolute; left: -1.5px; top: 30px; width: 20px; height: 1.5px; background: var(--indigo); }
.tflist__targets li::after { content: ""; position: absolute; left: 18px; top: 25.25px; width: 0; height: 0; border-top: 5.5px solid transparent; border-bottom: 5.5px solid transparent; border-left: 8px solid var(--indigo); }
.tflist__targets li:last-child { border-left-color: transparent; }
.tflist__targets li:last-child::before { top: 0; height: 31.5px; width: 20px; background: none; border-left: 1.5px solid var(--indigo); border-bottom: 1.5px solid var(--indigo); border-bottom-left-radius: 10px; }
.tflist__targets li > .tflist__title, .tflist__targets li > .tflist__sub { padding-left: 4px; }
.tflist__title { font-size: 18px; font-weight: 600; color: var(--ink); line-height: 1.4; }
.tflist__sub { margin-top: 2px; font-size: 17px; color: var(--muted); line-height: 1.45; }
.tflist__side { margin: 14px 0 0 4px; padding: 12px 0 0 18px; border-left: 1.5px solid var(--line-strong); border-top: 1px solid var(--line); }

@media (max-width: 1023px) {
  .tfmap__svg { display: none; }
  .tflist { display: block; }
}


/* ---------- Pipeline: program table (homepage .pipe table, deck slide 18) ---------- */
.pipe-page .pipe { margin-top: 0; }
.pipe-page .pipe__table thead th:first-child, .pipe-page .pipe__table tbody th { padding-left: 20px; }
.pipe-page .pipe__table tbody td.pipe__ms { padding-right: 20px; }
.pipe-page .pipe__table thead th:last-child { padding-left: 32px; }
.pipe__row--lead { background: var(--white); outline: 1px solid var(--indigo); outline-offset: -1px; }
.pipe-page .pipe__ms { vertical-align: middle; }
.pipe__lines { list-style: none; margin: 0; padding: 0; }
.pipe__lines li { padding: 8px 0; border-top: 1px solid var(--line); color: var(--text); line-height: 1.45; }
.pipe__lines li:first-child { border-top: 0; padding-top: 0; }
.pipe__lines li:last-child { padding-bottom: 0; }
.pipe__lines li.pipe__muted { color: var(--muted); }
.pipe-page .pipe__funding { margin-bottom: 8px; color: var(--muted); }
.pipe--partner { margin-top: 88px !important; }
.pipe__subhead { margin-bottom: 28px; font-size: clamp(26px, 2.2vw, 32px); line-height: 1.2; }
.track__bar--dr { width: 75%; background: var(--emerald); }
.track__bar--dr::after { border-color: var(--emerald); }
.track__note { position: absolute; left: 0; width: 75%; top: calc(50% + 16px); padding-right: 16px; font-size: 16px; line-height: 1.4; color: var(--ink); }
.track--dr .track__bar { top: 36%; }
.track--dr .track__note { top: calc(36% + 16px); }
.pipe-page .source-note { margin-top: 40px; }

/* ---------- Pipeline: SOLACE-1 (deck slide 19) ---------- */
.facts { list-style: none; margin: 56px 0 0; padding: 28px 0 0; display: grid; grid-template-columns: repeat(4, minmax(0, 1fr)); border-top: 1px solid rgba(255, 255, 255, .22); }
.facts li { padding: 0 24px; font-size: 18px; font-weight: 500; color: var(--white); line-height: 1.4; }
.facts li:first-child { padding-left: 0; }
.facts li + li { border-left: 1px solid rgba(255, 255, 255, .22); }

.tl-wrap { margin: 0; }
.tl {
  display: grid; grid-template-columns: repeat(20, minmax(0, 1fr)) 28px repeat(7, minmax(0, 1fr));
  grid-template-rows: auto 10px 52px auto auto; align-items: end;
}
.tl__label { grid-row: 1; align-self: end; padding: 0 8px 14px 0; font-size: 16px; font-weight: 500; line-height: 1.35; color: var(--ink); }
.tl__label--ext { color: var(--muted); font-weight: 400; font-style: italic; }
.tl__bar { grid-row: 2; height: 10px; margin-right: 3px; border-radius: var(--r-pill); transform-origin: left center; }
.tl__bar--screen { background: #eeedfb; box-shadow: inset 0 0 0 1px rgba(40, 32, 152, .45); }
.tl__bar--induct { background: var(--indigo); }
.tl__bar--follow { background: #6c63d6; margin-right: 0; }
.tl__bar--ext { margin-right: 0; background: none; border: 1.5px dashed #6c63d6; }
.tl__tick { grid-row: 3; position: relative; align-self: stretch; }
.tl__tick::before { content: ""; position: absolute; left: 0; top: 0; width: 1px; height: 12px; background: var(--indigo); }
.tl__tick > span { position: absolute; left: 0; top: 18px; transform: translateX(-50%); white-space: nowrap; font-family: var(--sans); font-size: 16px; color: var(--muted); line-height: 1; }
.tl__tick--first > span { transform: none; }
.tl__marker { grid-row: 4; position: relative; align-self: start; padding: 22px 0 0 14px; font-size: 16px; line-height: 1.4; color: var(--ink); }
.tl__marker::before { content: ""; position: absolute; left: 0; top: 0; width: 1.5px; height: 44px; background: var(--emerald); }
.tl__marker--end { padding: 22px 14px 0 0; text-align: right; }
.tl__marker--end::before { left: auto; right: 0; }
.tl__diary { grid-row: 5; margin-top: 24px; padding: 14px 20px; border: 1px solid var(--line-strong); border-radius: var(--r-btn); background: var(--cloud); font-size: 16px; line-height: 1.45; color: var(--text); text-align: center; }
.js .tl__bar { transform: scaleX(0); transition: transform .9s var(--ease) calc(.3s + var(--k) * .45s); }
.js .is-in .tl__bar { transform: none; }

.tl-list { display: none; }

.design { display: grid; grid-template-columns: repeat(4, minmax(0, 1fr)); gap: 24px; margin-top: 56px; }
.design__panel { padding: 28px 24px 24px; background: var(--white); border: 1px solid var(--line); border-radius: var(--r-card); }
.design__title { font-size: 21px; line-height: 1.2; padding-bottom: 16px; border-bottom: 1px solid var(--indigo); }
.design__list { list-style: none; margin: 0; padding: 0; }
.design__list li { padding: 12px 0; border-top: 1px solid var(--line); font-size: 16px; line-height: 1.45; color: var(--text); }
.design__list li:first-child { border-top: 0; }
.design__sub { display: block; margin-top: 6px; color: var(--muted); }
.design__list li.design__or { padding: 6px 0; font-weight: 600; color: var(--indigo); letter-spacing: .04em; border-top: 0; }
.design__list li.design__or + li { border-top: 0; }
.design__note { margin-top: 8px; padding-top: 12px; border-top: 1px solid var(--line-strong); font-size: 16px; line-height: 1.45; color: var(--muted); font-style: italic; }
.overlap--solace .source-note { margin-top: 40px; }

@media (max-width: 1240px) {
  .design { grid-template-columns: repeat(2, minmax(0, 1fr)); }
}
@media (max-width: 979px) {
  .pipe-page .pipe__table tbody th, .pipe-page .pipe__table tbody td { padding-left: 0; padding-right: 0; }
  .pipe-page .pipe__table tbody td.pipe__ms { padding: 20px 0 0 !important; }
  .pipe__row--lead { outline: 0; background: none; }
  .pipe-page .pipe__table tbody tr.pipe__row--lead { border-top: 2px solid var(--indigo); }
  .pipe-page .track__trial { display: block; top: auto; bottom: 8px; transform: none; left: calc(50% + 10px); padding: 0 6px 0 2px; background: var(--cloud); } /* masks the Phase 3 gridline behind the label */
  .track--dr .track__bar { top: auto; }
  .track--dr { padding-bottom: 24px; }
  .track__note { display: block; position: static; width: auto; padding: 12px 0 0; }
  .track--dr .track__bar { bottom: auto; top: 46px; }
  .track--dr .track__note { padding-top: 30px; }
  .pipe--partner { margin-top: 64px !important; }
  .facts { grid-template-columns: 1fr 1fr; row-gap: 20px; }
  .facts li:nth-child(3) { padding-left: 0; border-left: 0; }
  .tl { display: none; }
  .tl-list { display: block; list-style: none; margin: 0; padding: 0; }
  .tl-list__item { position: relative; padding: 0 0 32px 28px; }
  .tl-list__item::before { content: ""; position: absolute; left: 0; top: 4px; bottom: 8px; width: 8px; border-radius: var(--r-pill); }
  .tl-list__item--screen::before { background: #eeedfb; box-shadow: inset 0 0 0 1px rgba(40, 32, 152, .45); }
  .tl-list__item--induct::before { background: var(--indigo); }
  .tl-list__item--follow::before { background: #6c63d6; }
  .tl-list__item--ext { padding-bottom: 0; }
  .tl-list__item--ext::before { background: none; border: 1.5px dashed #6c63d6; }
  .tl-list__when { font-family: var(--sans); font-size: 16px; color: var(--muted); }
  .tl-list__ticks { color: var(--muted); }
  .tl-list__what { margin-top: 4px; font-size: 18px; font-weight: 500; color: var(--ink); line-height: 1.4; }
  .tl-list__item--ext .tl-list__what { font-weight: 400; font-style: italic; color: var(--muted); }
  .tl-list__note { position: relative; margin-top: 10px; padding-left: 16px; font-size: 16px; color: var(--text); line-height: 1.45; }
  .tl-list__note::before { content: ""; position: absolute; left: 0; top: 10px; width: 8px; height: 1.5px; background: var(--emerald); }
  .tl-list__note--box { padding: 12px 16px; border: 1px solid var(--line-strong); border-radius: var(--r-btn); background: var(--cloud); }
  .tl-list__note--box::before { display: none; }
  .tl-list__at { font-family: var(--sans); color: var(--muted); margin-right: 6px; }
}
@media (min-width: 980px) {
  .tl-list { position: absolute; width: 1px; height: 1px; overflow: hidden; clip: rect(0 0 0 0); white-space: nowrap; }
}
@media (max-width: 600px) {
  .facts { grid-template-columns: 1fr; row-gap: 0; padding-top: 8px; }
  .facts li, .facts li + li { padding: 14px 0; border-left: 0; border-bottom: 1px solid rgba(255, 255, 255, .22); }
  .facts li:last-child { border-bottom: 0; }
  .design { grid-template-columns: 1fr; gap: 16px; }
  .design__panel { padding: 24px 18px 20px; }
}
@media (prefers-reduced-motion: reduce) {
  .js .tl__bar { transform: none; }
}


/* ---------- Team (deck slide 3): hairline grid; photos, names and roles align, Background lines sit on a shared bottom line ---------- */
.team-page { background: var(--cloud); }
.leaders { list-style: none; margin: 0; padding: 0; display: grid; grid-template-columns: repeat(3, minmax(0, 1fr)); column-gap: 56px; row-gap: 0; }
.leader { display: grid; grid-row: span 5; grid-template-rows: subgrid; row-gap: 0; align-items: start; justify-items: start; padding-top: 36px; border-top: 1px solid var(--line-strong); }
.leaders > .leader:nth-child(n+4) { margin-top: 72px; }
.leader .person__photo { width: 116px; height: 116px; background: var(--white); }
.leader__name { margin-top: 26px; font-size: 26px; line-height: 1.2; }
.leader__cred { color: var(--muted); }
.leader__role { margin-top: 8px; font-size: 16px; font-weight: 500; color: var(--indigo); line-height: 1.45; }
.leader__bio { margin: 18px 0 20px; font-size: 16px; line-height: 1.6; color: var(--text); }
.leader__bg { justify-self: stretch; padding-top: 14px; border-top: 1px solid var(--line); font-size: 16px; line-height: 1.5; color: var(--muted); }
.leader__bg-label { font-weight: 600; color: var(--ink); }

/* ---------- Publications: filter chips + hairline rows ---------- */
.pub-filter { display: flex; flex-wrap: wrap; gap: 10px; margin-bottom: 64px; }
.pub-filter__btn { cursor: pointer; font: 500 16px/1 var(--sans); transition: background-color .3s var(--ease), border-color .3s var(--ease); }
.pub-filter__btn:hover { border-color: var(--indigo); }
.pub-filter__btn[aria-pressed="true"] { background: var(--tint); border-color: var(--indigo); color: var(--ink); }
.pub-groups { border-bottom: 1px solid var(--line-strong); }
/* One full-width hairline between categories: each group draws its top line; rows inside draw only the lines between them. */
.pub-group { display: grid; grid-template-columns: minmax(0, 4fr) minmax(0, 8fr); gap: 80px; padding-bottom: 32px; border-top: 1px solid var(--line-strong); }
.pub-group .pub-list { border-bottom: 0; }
.pub-group .pub:first-child { border-top: 0; }
.pub-group[hidden] { display: none; }
.pub-group__title { font-size: clamp(28px, 2.6vw, 38px); line-height: 1.15; padding-top: 30px; }
.pub--row .pub__title { margin-top: 0; font-size: clamp(21px, 1.8vw, 25px); line-height: 1.3; color: var(--ink); }
.pub__journal { margin-top: 4px; font-size: 16px; color: var(--muted); }
.pub-badge {
  display: inline-flex; align-items: center; height: 26px; margin-left: 10px; padding: 0 10px; vertical-align: 1px;
  border: 1px solid rgba(0, 168, 64, .45); border-radius: var(--r-pill); background: rgba(0, 168, 64, .07);
  font-size: 16px; font-weight: 600; line-height: 1; letter-spacing: .03em; color: var(--emerald);
}
.pub__links { display: flex; flex-wrap: wrap; gap: 8px 28px; margin-top: 16px; }
.pub__link { font-size: 16px; font-weight: 500; color: var(--indigo); text-decoration: none; padding-bottom: 3px; border-bottom: 1px solid var(--line-strong); transition: border-color .3s var(--ease); }
.pub__link:hover { border-bottom-color: var(--emerald); }

/* ---------- Press releases ---------- */
.press-list { max-width: 900px; }
.press-empty__line { font-size: 20px; color: var(--muted); }
.press-empty .text-link { margin-top: 20px; }
.press-row__date { font-family: var(--sans); font-size: 16px; color: var(--muted); }
.press-row__title { margin-top: 10px; font-family: var(--serif); font-weight: 400; font-size: clamp(21px, 1.9vw, 26px); line-height: 1.3; }
.press-row__title a { color: var(--ink); text-decoration: none; }
.press-row__line { margin-top: 8px; font-size: 17px; color: var(--muted); }

/* ---------- Contact ---------- */
.contact-page { background: var(--cloud); }
.contact__grid { display: grid; grid-template-columns: minmax(0, 5fr) minmax(0, 7fr); gap: 80px; align-items: start; }
.contact__title { font-size: clamp(32px, 3vw, 44px); }
.contact__links { list-style: none; margin: 32px 0 0; padding: 0; }
.contact__links .text-link { margin-top: 12px; }
.contact__card { padding: 48px 48px 44px; background: var(--white); border-radius: var(--r-panel); box-shadow: 0 30px 70px -40px rgba(21, 16, 107, .3), 0 0 0 1px rgba(21, 16, 107, .05); }
.form__field + .form__field { margin-top: 24px; }
.form__label { display: block; margin-bottom: 8px; font-size: 16px; font-weight: 500; color: var(--ink); }
.form__req { font-weight: 400; color: var(--muted); }
.form__input {
  display: block; width: 100%; min-height: 54px; padding: 12px 16px; border: 1px solid var(--line-strong); border-radius: var(--r-btn);
  background: var(--white); font: 400 18px/1.4 var(--sans); color: var(--text); transition: border-color .3s var(--ease), box-shadow .3s var(--ease);
}
.form__input:hover { border-color: var(--indigo); }
.form__input:focus { outline: none; border-color: var(--indigo); box-shadow: 0 0 0 3px rgba(0, 168, 64, .35); }
.form__select { appearance: none; padding-right: 44px; cursor: pointer;
  background: var(--white) url("data:image/svg+xml,%3Csvg xmlns='http://www.w3.org/2000/svg' width='12' height='8' viewBox='0 0 12 8'%3E%3Cpath d='M1 1.5l5 5 5-5' fill='none' stroke='%23282098' stroke-width='1.5'/%3E%3C/svg%3E") no-repeat right 18px center; }
.form__textarea { min-height: 160px; resize: vertical; }
.form__input[aria-invalid="true"] { border-color: var(--indigo); box-shadow: inset 3px 0 0 var(--emerald); }
.form__error { margin-top: 8px; font-size: 16px; color: var(--ink); padding-left: 14px; position: relative; }
.form__error::before { content: ""; position: absolute; left: 0; top: 9px; width: 8px; height: 8px; border-radius: 50%; background: var(--emerald); }
.form__submit { margin-top: 36px; cursor: pointer; }
.form__done { font-family: var(--serif); font-weight: 300; font-size: 26px; line-height: 1.35; color: var(--ink); padding: 8px 0; }
.form__done:focus { outline: none; }

@media (max-width: 1100px) {
  .leaders { grid-template-columns: repeat(2, minmax(0, 1fr)); column-gap: 48px; }
  .leaders > .leader:nth-child(n+3) { margin-top: 64px; }
  .pub-group { grid-template-columns: 1fr; gap: 0; }
  .pub-group .pub:first-child { padding-top: 20px; }
  .contact__grid { grid-template-columns: 1fr; gap: 48px; }
}
@media (max-width: 719px) {
  .leaders { grid-template-columns: 1fr; row-gap: 48px; }
  .leader { display: block; grid-row: auto; padding-top: 32px; }
  .leaders > .leader:nth-child(n+2) { margin-top: 48px; }
  .leader .person__photo { width: 104px; height: 104px; }
}
@media (max-width: 600px) {
  .leader__name { font-size: 24px; }
  .pub-filter { margin-bottom: 48px; }
  .contact__card { padding: 28px 18px 28px; margin: 0 -2px; }
}

/* ---------- Inner pages: responsive ---------- */
@media (max-width: 1100px) {
  .overlap__panel { padding: 56px 40px 48px; }
}
@media (max-width: 979px) {
  .hero--page { padding: 40px 0 72px; }
  .hero--page .hero__grid { grid-template-columns: minmax(0, 1fr) 190px; gap: 32px; align-items: center; }
  .hero--page .hero__art { position: static; top: auto; right: auto; width: auto; max-width: none; }
  .hero--page .mark--hero { width: 100%; }
}
@media (max-width: 719px) {
  .hero--page .hero__grid { grid-template-columns: 1fr; }
  .hero--page .hero__art { display: none; }
  .rx .rx__svg--wide { display: none; }
  .rx .rx__svg--tall { display: block; }
}
@media (max-width: 600px) {
  .hero--page { padding: 32px 0 56px; }
  .hero--page .hero__title { font-size: 34px; line-height: 1.14; margin: 20px 0 24px; }
  .hero--page .hero__lede { font-size: 18px; margin-top: 24px; }
  .band { padding: 80px 0 168px; }
  .band__sub { font-size: 18px; }
  .overlap__panel { margin-top: -96px; padding: 36px 18px 32px; }
}

@media (prefers-reduced-motion: reduce) {
  .js .draw .rx__x, .js .draw .rx__dna { opacity: 1; }
  .js .tfmap .tfmap__line { stroke-dashoffset: 0; }
  .js .tfmap .tfmap__arrow { opacity: 1; }
}

/* =====================================================================
   Inner page hero graphics (brief/BRIEF-heroes-v2.md, 26 Sep 2026).
   Same technique as the homepage mark: thin contour stripes that draw in one
   after another (draw keyframes, dasharray 1), then slow ambient motion
   (fold per stripe, breathe on the whole mark). Markup: tools/gen/heroes.py.
   ===================================================================== */
.hero--page .mark--art { width: 100%; max-width: 330px; }
.mark__stripes--indigo path { stroke: var(--indigo); stroke-width: .95; }
.mark__stripes--emerald path { stroke: var(--emerald); stroke-width: 1.1; }
.mark--art .mark__stripes path {
  animation: draw 1s cubic-bezier(.45, .05, .25, 1) var(--d) forwards,
             fold 13s ease-in-out calc(3s + var(--i) * .37s) infinite alternate;
}
.mark__grid, .mark__base { fill: none; stroke: var(--indigo); stroke-width: .8; }
.mark__grid { stroke-opacity: .16; }
.mark__base { stroke-opacity: .4; }
.mark__dot { fill: var(--indigo); }
.mark__dots .mark__dot { fill-opacity: .18; }
.mark__gridlines, .mark__dots, .mark__origin { opacity: 0; animation: fade .8s ease .1s forwards; }
.mark__dots { animation-delay: 2.2s; }

/* Team: the ring turns very slowly (one turn in 5 minutes). */
.mark__spin { transform-box: view-box; transform-origin: 130px 125px; animation: spin 300s linear 3s infinite; }
@keyframes spin { to { transform: rotate(360deg); } }

/* Press releases: arcs fade outward from the origin and pulse outward in sequence. */
.mark--art-press .mark__stripes { opacity: var(--op); transform-box: view-box; transform-origin: 34px 125px; animation: pulse 12s ease-in-out calc(3s + var(--a) * .9s) infinite; }
@keyframes pulse { 0%, 100% { transform: scale(1); } 50% { transform: scale(1.03); } }

/* Contact: the two tips drift very slightly toward and away from each other (gap never closes). */
.mark--art-contact [data-side="left"] { animation: near-l 12s ease-in-out 3s infinite alternate; }
.mark--art-contact [data-side="right"] { animation: near-r 12s ease-in-out 3s infinite alternate; }
@keyframes near-l { from { transform: translate(-1px, -.9px); } to { transform: translate(1.6px, 1.4px); } }
@keyframes near-r { from { transform: translate(1px, .9px); } to { transform: translate(-1.6px, -1.4px); } }

@media (max-width: 979px) {
  .hero--page .mark--art .mark__stripes--indigo path { stroke-width: 1.2; }
  .hero--page .mark--art .mark__stripes--emerald path { stroke-width: 1.35; }
}
@media (max-width: 719px) {
  .hero--page .hero__art { display: flex; justify-content: center; margin-top: 36px; }
  .hero--page .mark--art { width: auto; height: 220px; max-width: 100%; }
}

/* =====================================================================
   Footer in columns (Darya, 26 Sep 2026): brand + tagline, then Company /
   Resources / Contact link columns; bottom bar unchanged. Overrides the
   single-row footer rules above.
   ===================================================================== */
.site-footer__top { display: grid; grid-template-columns: minmax(0, 4fr) minmax(0, 8fr); gap: 48px 64px; align-items: start; }
.site-footer__logo { display: inline-block; }
.site-footer__tagline { margin-top: 20px; max-width: 34ch; font-size: 16px; line-height: 1.6; color: var(--muted); }
.site-footer__cols { display: grid; grid-template-columns: repeat(3, minmax(0, 1fr)); gap: 32px; }
.site-footer__head { font-size: 16px; font-weight: 600; color: var(--indigo); line-height: 1.4; }
.site-footer .site-footer__nav { display: flex; flex-direction: column; gap: 12px; margin-top: 18px; }
.site-footer__nav a { line-height: 1.4; }

@media (max-width: 1100px) {
  .site-footer__top { grid-template-columns: 1fr; }
}
@media (max-width: 600px) {
  .site-footer__top { display: grid; }
  .site-footer__cols { grid-template-columns: 1fr 1fr; row-gap: 36px; }
  .site-footer__col:last-child { grid-column: 1 / -1; }
  .site-footer__bottom { flex-direction: column; gap: 12px; }
}

/* Science hero v4 (cartoon): surface contours draw first, then the chain N to C (~2.5 s) as consecutive segments;
   ambient motion is the whole mark breathing only, so segment joins never drift apart. */
.mark--art-science .rx-chain path { animation: draw var(--dur) linear var(--d) forwards; }
.mark--art-science .rx-surface { opacity: .16; }

/* Inner hero graphics v3 (brief/BRIEF-heroes-v3.md): wider art column, bigger graphics. */
.hero--page .hero__grid { grid-template-columns: minmax(0, 7fr) minmax(0, 5fr); gap: 48px; }
.hero--page .hero__art { justify-content: center; }
.hero--page .mark--art { width: 100%; max-width: 520px; max-height: 440px; }
@media (max-width: 979px) {
  .hero--page .hero__grid { grid-template-columns: minmax(0, 1fr) minmax(0, 38%); gap: 28px; }
  .hero--page .mark--art { max-height: none; }
}
@media (max-width: 719px) {
  .hero--page .hero__grid { grid-template-columns: 1fr; }
  .hero--page .hero__art { margin-top: 24px; }
  .hero--page .mark--art { width: 100%; height: auto; max-height: 280px; }   /* viewBox fitted to the drawing by main.js */
}
/* Pipeline v3: after the arrows draw, a very slow shimmer runs across the stripes. */
.mark--art-pipeline .mark__stripes path {
  animation: draw 1s cubic-bezier(.45, .05, .25, 1) var(--d) forwards,
             shimmer 9s ease-in-out calc(3.2s + var(--i) * .18s) infinite alternate;
}
@keyframes shimmer { from { opacity: 1; } to { opacity: .5; } }
/* Publications v3: the central ring (the conclusion) pulses very slowly. */
.mark__dot--em { fill: var(--emerald); }
.mark__hub { transform-box: view-box; transform-origin: 178px 125px; animation: hub 10s ease-in-out 3.5s infinite alternate; }
@keyframes hub { from { transform: scale(1); } to { transform: scale(1.08); } }

/* ---------- Home: "De-risked, mid-stage drug" band (deck slides 4, 10, 24; client request via Madison, 16 Sep) ---------- */
.derisk { background: var(--cloud); padding: 104px 0; }
.derisk .figures { margin-top: 56px; }
.derisk .figure__num { font-size: clamp(48px, 4.4vw, 64px); padding-bottom: 14px; }
.derisk .figure__title { font-weight: 400; color: var(--text); font-size: 18px; line-height: 1.45; }
.derisk .source-note { margin-top: 40px; }
@media (max-width: 600px) {
  .derisk { padding: 80px 0; }
  .derisk .figures { grid-template-columns: 1fr 1fr; }
  .derisk .figure, .derisk .figure + .figure { padding: 28px 12px 8px 0; border-left: 0; border-top: 0; margin-top: 0; }
  .derisk .figure:nth-child(even) { padding-left: 16px; border-left: 1px solid var(--line); }
  .derisk .figure:nth-child(n+3) { border-top: 1px solid var(--line); }
  .derisk .figure__title { font-size: 16px; }
}

/* Pipeline hero on phones: short phase hairlines (the phone viewBox is fitted to them) and a taller cap so it reads full width. */
.mark__grid--phone { display: none; }
@media (max-width: 719px) {
  .mark--art-pipeline .mark__grid--desk { display: none; }
  .mark--art-pipeline .mark__grid--phone { display: inline; }
  .hero--page .mark--art-pipeline { max-height: 320px; }
}

/* =====================================================================
   Round 8 (Darya's phone review, 26 Sep 2026)
   ===================================================================== */
/* Mobile menu: full-screen white panel; the header row (logo + close) stays on top; page behind is locked. */
@media (max-width: 979px) {
  .site-header.is-menu-open { background: var(--white); -webkit-backdrop-filter: none; backdrop-filter: none; border-bottom-color: var(--line); }
  .site-header__logo, .nav-toggle { position: relative; z-index: 2; }
  .site-nav.is-open {
    position: fixed; inset: 0; z-index: 1; display: block; overflow-y: auto; overscroll-behavior: contain;
    padding-top: 96px; background: var(--white); border-bottom: 0;
  }
  html.menu-open, html.menu-open body { overflow: hidden; }
  html.menu-open body { position: fixed; left: 0; right: 0; width: 100%; }
  html.menu-open .site-header { position: fixed; top: 0; left: 0; right: 0; }   /* body is fixed at -scrollY, so keep the header row pinned */
}

/* Homepage hero on phones: the mark sits centred above the chip in its own space. Tablet and desktop unchanged. */
@media (max-width: 719px) {
  .hero:not(.hero--page) .hero__grid { display: flex; flex-direction: column; }
  .hero:not(.hero--page) .hero__art { position: static; order: -1; align-self: center; width: 170px; max-width: none; margin: 0 0 20px; top: auto; right: auto; }
  .hero:not(.hero--page) .mark--hero { width: 100%; margin: 0; }
}

/* Pipeline DR row on phones and tablets: the phase gridlines stop under the bar; the note sits below them. */
@media (max-width: 979px) {
  .track--dr { padding-bottom: 0; }
  .track--dr::before { bottom: auto; height: 64px; }
  .track--dr .track__note { padding-top: 30px; }
}

/* Publications: titles link to the DOI (existing emerald underline on hover), visible on keyboard focus too. */
.pub--row .pub__title a { color: var(--ink); }
.pub__title a:focus-visible { background-size: 100% 1.5px; }

/* Pipeline table at 980-1240 px: keep "APX3330" inside its column, and set the DR note below the phase gridlines. */
@media (min-width: 980px) and (max-width: 1240px) {
  .pipe-page .pipe__program { font-size: 19px; }
  .pipe-page .pipe__table thead th:first-child, .pipe-page .pipe__table tbody th { padding-left: 14px; }
  .track--dr { min-height: 150px; }
  .track--dr::before { bottom: 58px; }
  .track--dr .track__bar { top: 34px; margin-top: 0; }
  .track--dr .track__note { top: auto; bottom: 6px; width: 100%; padding-right: 8px; }
}

/* Oct 2026: "$15B US IBD market" band removed. The profile panel used to overlap that band (negative margin);
   it now sits inside its own tinted section. */
.profile { padding-top: 96px; }
.profile__panel { margin-top: 0; }
@media (max-width: 600px) {
  .profile { padding-top: 56px; }
  .profile__panel { margin-top: 0; }
}

/* Oct 2026: page-name chips removed above hero titles. */
.hero__text > .hero__title:first-child { margin-top: 0; }

/* Oct 2026: treatment-gap stats shown as pie charts (replaces the 10-circle marker rows and the key). */
.gap__grid { align-items: stretch; }
.people-gap { justify-content: center; padding: 40px 40px; }
.gap-stat { display: grid; grid-template-columns: 132px minmax(0, 1fr); align-items: center; column-gap: 36px; padding: 36px 0; }
.gap-stat:last-child { padding-bottom: 0; }
.pie { width: 132px; height: 132px; display: block; transform: rotate(-90deg); }
.pie__track { fill: var(--white); stroke: var(--line-strong); stroke-width: 1.5; }
.pie__slice {
  fill: none; stroke: var(--indigo); stroke-width: 56;
  stroke-dasharray: var(--pct) 100; stroke-dashoffset: 0;
  transition: stroke-dasharray 1.4s var(--ease) .4s;
}
.js .people-gap .pie__slice { stroke-dasharray: 0 100; }
.js .people-gap.is-in .pie__slice { stroke-dasharray: var(--pct) 100; }
.gap-stat .people-gap__num { font-size: 40px; line-height: 1; }
.gap-stat .people-gap__label { margin: 10px 0 0; font-size: 18px; line-height: 1.5; max-width: 26em; }
@media (prefers-reduced-motion: reduce) { .pie__slice { transition: none; } }
@media (max-width: 600px) {
  .people-gap { padding: 28px 20px; }
  .gap-stat { grid-template-columns: 88px minmax(0, 1fr); column-gap: 20px; padding: 28px 0; }
  .pie { width: 88px; height: 88px; }
  .gap-stat .people-gap__num { font-size: 32px; }
  .gap-stat .people-gap__label { font-size: 16px; }
}

/* Oct 2026: IBD footprint updated to CDC NCHS Health E-Stat 122 (CD 1.3M, UC 3.1M adults); "Other IBD" segment removed. */
.fp { --cd: 1.3; --uc: 3.1; --sum: 4.4; }
.fp__seg--cd { flex: 0 0 calc((100% - var(--gap)) * var(--cd) / var(--sum)); }
.fp__seg--uc { flex: 1 1 0; }
.fp__keys { grid-template-columns: calc((100% - var(--gap)) * var(--cd) / var(--sum)) 1fr; }
.site-footer__tag-name { font-size: 18px; font-weight: 600; color: var(--indigo); }